Coleman Upton PhD
Dec 31, 2024
Using the gas pedal analogy explain the impact on the cell cycle of one mutated tumor suppressor gene allele versus two mutated tumor
Using the gas pedal analogy, a proto-oncogene acts like an accelerator, as it promotes cell division and deregulates apoptosis. In contrast, a tumor suppressor gene functions like the brakes, as it restrains the progress of the cell cycle and induces apoptosis. Therefore, when a proto-oncogene becomes mutated, it can be likened to an accelerator that is stuck in the down position, while the tumor suppressor genes are not functioning properly. This situation can lead to uncontrolled cell growth. Now, let's consider the impact of one mutated tumor suppressor gene allele versus two mutated alleles on the cell cycle. How does each scenario affect cell division and the overall regulation of the cell cycle?
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