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Chemotherapy

#Oncology #Chemotherapeutic agents #Cancer treatments

1 Solutions to this problem include ________ (both brachytherapy and teletherapy) and surgery.

2 The CTZ is in the ________, outside the blood-brain barrier, and is thus susceptible to stimulation by substances present in the blood or cerebral spinal fluid.

3 Specific chemotherapeutic agents are associated with organ-specific toxicities, including ________ (e.g., doxorubicin), interstitial lung disease (e.g., bleomycin) and occasionally secondary neoplasm (e.g., MOPP therapy for Hodgkin's disease).

4 Vinca alkaloids bind to specific sites on tubulin, inhibiting the assembly of tubulin into microtubules (________ of the cell cycle).

5 A granisetron ________ (Sancuso) was approved by the FDA in September 2008.

6 Self-care measures, such as eating frequent small meals and drinking clear liquids or ________ tea, are often recommended.

7 Medications that kill rapidly dividing cells or blood cells are likely to reduce the number of ________ in the blood, which can result in bruises and bleeding.

8 lymphoid: ________ (Ibritumomab, Ofatumumab, Rituximab, Tositumomab), CD52 (Alemtuzumab)

9 This means that other fast-dividing cells, such as those responsible for hair growth and for replacement of the intestinal ________ (lining), are also often affected.

10 ________ is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis.

💡 Interesting Facts

  • targeted therapy is a type of chemotherapy which blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth?
  • halomon (chemical structure pictured), a natural halogenated organic compound isolated from red algae, shows early preclinical promise as a potential antitumor agent?
  • synthetic analogues of camptothecin, a cytotoxic quinoline alkaloid isolated from the Chinese tree Camptotheca acuminata, are being used as anti-cancer drugs?
  • the edible fungus Polyozellus multiplex (pictured) has attracted research interest as a possible chemopreventative agent against stomach cancer?
  • the first registered clinical use of an NK1 receptor blocker was the treatment of nausea and vomiting induced by chemotherapy?
  • the most recent of the six different methods of total synthesis of the anti-cancer drug paclitaxel, a drug originally derived from the rare Pacific Yew, was developed at the Tokyo University of Science in 1999?
  • drug-eluting stents are often coated with chemotherapy compounds, to prevent blockage by tissue when placed into arteries?
  • DirectHit is the only accurate pharmacodiagnostic test to determine possible treatment outcomes of anticancer chemotherapy drugs for breast cancer?
  • 5-HT3 antagonists, effective for treating the nausea and vomiting due to chemotherapy, have no effect on motion sickness?
  • Mdm2, whose role in regulating p53 was discovered by British scientist Karen Vousden, is a potential target for anti-cancer drugs?
  • Body surface area is an important measure used in medicine to calculate chemotherapy dosage?
  • body surface area is an important measure used in medicine to calculate chemotherapy dosage?
  • Bubba the Grouper, the first known fish to receive chemotherapy, died recently in Chicago, Illinois?
  • Japanese scientists have found anticancer activity in some Brazilian traditional remedies?
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