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Anonymous

Dec 22, 2024

Why does an enzyme not work as well if its active site is changed?

Why does an enzyme's functionality decrease when its active site is altered? Specifically, I would like to understand the mechanisms behind this phenomenon and how changes to the active site affect the enzyme's ability to bind to substrates and catalyze reactions.

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2 Answers

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Anonymous

Jan 11, 2025

Enzymes are generally very carefully formed in order to catalyze a specific reaction for a specific molecule. The active site is folded in such as way to just allow the desired substrate to fit into it (like a puzzle piece), so changing the site will make it more difficult for this binding to occur. If the binding is more difficult the reaction will be inhibited, hence the enzyme won't work as well(if at all).
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Anonymous

Dec 24, 2024

As the enzyme works on the lock and key hypothesis, meaning that it's active site is complementary only to its substrate, when the active sites shape is changed then the substrate will no longer be complementary, this will lead to the enzyme not being able to catalyse the reaction and the rate of the reaction to decrease.
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Chemistry Biology History

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catalysis enzyme active site

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